NMR for polymorphism

We describe a new sample formulation for MAS DNP, showing that good sensitivity enhancements be obtained in water without glycerol (or other glass forming agents) simply by dissolving
high concentrations of electrolytes (such as NaCl or LiCl), which perturb the otherwise
unavoidable ice crystallization observed upon cooling, thereby reducing PA phase separation
and restoring DNP efficiency.

Giulia attended the ISMAR conference in Brisbane (AUS) where she gave an invited lecture on the study of polymorphic phase formation and transformation using hyperpolarized NMR. Stunning city and location, and excellent conference!

Pierre was at the Euromar 2023 in Glasgow where he gave a presentation on the use of MAS DNP for the early detection of polymorphic transformations in organic solids.

Prof Raffaella Demichelis from Curtin University in Australia visited the lab. She gave a beautiful talk on "Chemistry at the mineral-fluid interface: an atomic-scale perspective", very interesting topic and results. Thanks Raffaella!

Romain successfully defended his PhD! Congratulations to him and many thanks to the committee members Marco Geppi, Loriane Lecoq (rapporteurs), Christian Bonhomme and Danielle Laurencin for the nice discussion.

Céline Huart is the recipient of a PhD fellowship funded by the University of Aix-Marseille. Her interdisciplinary project will be carried out between the ICR and the CINaM laboratories in Marseille. She will combine hyperpolarized NMR and microfluidics for studying crystallization in confined environements. Stay tuned for exciting discoveries!

Congratulations to Samuel for his first publication with us! Great collaboration with Arthur Pinon (Gothenburg), Kenneth D.M. Harris and Colan E. Hughes (Cardiff) to show how far DNP can go to reveal the nanoscale morphology of mixtures of organic polymorphs.

Giulia and Sam attended the GERM conference on NMR in extreme conditions in Murol. Sam gave a beautiful talk on the study of morphology of organic particles by MAS DNP. We had very lively discussions and lot of fun in a beautiful environment by the lake, surrounded by ancient volcanos.

Giulia gave an invited talk to the spin hyperpolarization symposium organized by the University of Nottingham. Lots of interesting talks and discussions, food for the mind!

Congratulations Marie for this new pedagogical review presenting nuclear magnetic resonance strategies for time-resolved atomic-level investigation of crystallization from solution. There is an interesting section on perspectives and future directions in the field. Non specialists are welcome!

Another good news! Giulia has been appointed Distinguished Junior Member (Membre Distingué Junior) by the French Chemical Society.

Great news! Giulia has been nominated for the Grand Prix Départemental pour la Recherche en Provence. The ceremony for the prize attribution will take place on the 2nd of December.

We show that additives that serve crystallization can also enhance the sensitivity of DNP.

Congrats to Sam for successfully passing his CNRS audition. He is now permanent CNRS Researcher!
All the group wishes him lots of success!

Giulia, Sam and Romain were in Chamonix to attend the Alpine Conference on Magnetic Resonance. Giulia gave a talk on the use of MAS DNP to investigate cristallisation and achieving polymorph selection. Romain and Sam gave two round tables showing recent results on the study of crystallization in inorganic systems and spin diffusion. Awesome conference with very lively formal and informal discussions.

The overall aim of the project is to develop and apply an emerging NMR hyperpolarization technique, namely magic-angle spinning nuclear dynamic polarization (MAS-DNP), to characterize the process of formation of polymorphic organic solids. To apply: https://emploi.cnrs.fr/Offres/CDD/UMR7273-GIUMOL-019/Default.aspx

We showed how supercritical CO2 impregnation can be efficiently used to disperse radicals used as polarizing agents for DNP into polymeric materials, enhancing the sensitivity of NMR towards the structural analysis of challenging materials.

Giulia and Romain participated to the PANACEA workshop on ssNMR methods for pharmaceutical formulations hosted by the group of Prof. L. Emsley in EPFL Lausanne. We had a fantastic week of lively discussions between coaches and students in front of the spectrometer and off!

We welcomed the MISOTOP group from the Institut Charles Gerhardt of Montpellier for the third MoMa meeting, where Marie, Samuel and Nghia gave a talk. We had a lot of fun discussing NMR, DNP, isotopic enrichment through mechanochemistry, recoupling methods, spin diffusion and crystallization.

Giulia presented our recent results on the use of MAS DNP for the study of crystallization and selection of polymorph at the online conference HyMar, organized by the Italian discussion group on Magnetic Resonance, GIDRM.

Dr Arthur Pinon from University of Gothenburg will stay with us for two weeks to work on spin diffusion. Welcome Arthur!

Nghia is going to work on methodological development in ssNMR and DNP.

Marie successfully defended her PhD on the 4th of March.
Bravo Marie for your hard work, resilience and perseverance, and for a brilliant and living discussion with the jury. Thank you to Anne Lesage and Christian Bonhomme for accepting to review Marie's PhD manuscript and for sharing with us this very happy moment. And thank you to Kenneth Harris and Paul Hogkinson for accepting to be part of the committee.

We are always looking for motivated candidates to join our group. Please contact Giulia Mollica at giulia.mollica@univ-amu.fr for information about currently available positions and projects.

Congratulations to Marie for this very nice review article on NMR and DNP methods for investigating crystallization from solution.